Evaluating the conformation of recombinant domain I of β(2)-glycoprotein I and its interaction with human monoclonal antibodies

Pathogenic antiphospholipid antibodies (aPL) cause the antiphospholipid syndrome (APS) by interacting with domain I (DI) of beta-2-glycoprotein I (β(2)GPI). The aPL/β(2)GPI complex then exerts pathogenic effects on target cells. We previously described periplasmic bacterial expression of native and...

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Main Authors: Pericleous, Charis, Miles, Jennifer, Esposito, Diego, Garza-Garcia, Acely, Driscoll, Paul C., Lambrianides, Anastasia, Latchman, David, Isenberg, David, Rahman, Anisur, Ioannou, Yiannis, Giles, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: Pergamon Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268385/
https://ncbi.nlm.nih.gov/pubmed/21899894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2011.07.024
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