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Pharmacophore-based discovery of a novel cytosolic phospholipase A(2)α inhibitor

The release of arachidonic acid, a precursor in the production of prostaglandins and leukotrienes, is achieved by activity of the cytosolic phospholipase A(2)α (cPLA(2)α). Signaling mediated by this class of bioactive lipids, which are collectively referred to as eicosanoids, has numerous effects in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Noha, Stefan M., Jazzar, Bianca, Kuehnl, Susanne, Rollinger, Judith M., Stuppner, Hermann, Schaible, Anja M., Werz, Oliver, Wolber, Gerhard, Schuster, Daniela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Science Ltd 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268354/
https://ncbi.nlm.nih.gov/pubmed/22192589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.11.093
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