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Pharmacophore-based discovery of a novel cytosolic phospholipase A(2)α inhibitor
The release of arachidonic acid, a precursor in the production of prostaglandins and leukotrienes, is achieved by activity of the cytosolic phospholipase A(2)α (cPLA(2)α). Signaling mediated by this class of bioactive lipids, which are collectively referred to as eicosanoids, has numerous effects in...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier Science Ltd
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3268354/ https://ncbi.nlm.nih.gov/pubmed/22192589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.11.093 |
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