Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E(2) Synthase-1 (mPGES-1)

[Image: see text] Microsomal prostaglandin E(2) synthase-1 (mPGES-1) catalyzes prostaglandin E(2) formation and is considered as a potential anti-inflammatory pharmacological target. To identify novel chemical scaffolds active on this enzyme, two pharmacophore models for acidic mPGES-1 inhibitors we...

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Main Authors: Waltenberger, Birgit, Wiechmann, Katja, Bauer, Julia, Markt, Patrick, Noha, Stefan M., Wolber, Gerhard, Rollinger, Judith M., Werz, Oliver, Schuster, Daniela, Stuppner, Hermann
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2011
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088311/
https://ncbi.nlm.nih.gov/pubmed/21466167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101309g
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