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Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol
Microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors are considered as potential therapeutic agents for the treatment of inflammatory pain and certain types of cancer. So far, several series of acidic as well as non-acidic inhibitors of mPGES-1 have been discovered. Acidic inhibitors, howev...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4528062/ https://ncbi.nlm.nih.gov/pubmed/26088337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.05.045 |
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