Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE(2) Levels

[Image: see text] Microsomal prostaglandin E(2) synthase-1 (mPGES-1), the terminal enzyme responsible for the production of inducible prostaglandin E(2), has become an attractive target for the treatment of inflammation and cancer pathologies. Starting from an aminobenzothiazole scaffold, used as an...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Med Chem Lett
मुख्य लेखकों: Chini, Maria G., Giordano, Assunta, Potenza, Marianna, Terracciano, Stefania, Fischer, Katrin, Vaccaro, Maria C., Colarusso, Ester, Bruno, Ines, Riccio, Raffaele, Koeberle, Andreas, Werz, Oliver, Bifulco, Giuseppe
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2020
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236256/
https://ncbi.nlm.nih.gov/pubmed/32435385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00618
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