Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE(2) Levels

[Image: see text] Microsomal prostaglandin E(2) synthase-1 (mPGES-1), the terminal enzyme responsible for the production of inducible prostaglandin E(2), has become an attractive target for the treatment of inflammation and cancer pathologies. Starting from an aminobenzothiazole scaffold, used as an...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Chini, Maria G., Giordano, Assunta, Potenza, Marianna, Terracciano, Stefania, Fischer, Katrin, Vaccaro, Maria C., Colarusso, Ester, Bruno, Ines, Riccio, Raffaele, Koeberle, Andreas, Werz, Oliver, Bifulco, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236256/
https://ncbi.nlm.nih.gov/pubmed/32435385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00618
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