Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE(2) Levels

[Image: see text] Microsomal prostaglandin E(2) synthase-1 (mPGES-1), the terminal enzyme responsible for the production of inducible prostaglandin E(2), has become an attractive target for the treatment of inflammation and cancer pathologies. Starting from an aminobenzothiazole scaffold, used as an...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Chini, Maria G., Giordano, Assunta, Potenza, Marianna, Terracciano, Stefania, Fischer, Katrin, Vaccaro, Maria C., Colarusso, Ester, Bruno, Ines, Riccio, Raffaele, Koeberle, Andreas, Werz, Oliver, Bifulco, Giuseppe
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236256/
https://ncbi.nlm.nih.gov/pubmed/32435385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00618
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