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Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol

Microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors are considered as potential therapeutic agents for the treatment of inflammatory pain and certain types of cancer. So far, several series of acidic as well as non-acidic inhibitors of mPGES-1 have been discovered. Acidic inhibitors, howev...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Noha, Stefan M., Fischer, Katrin, Koeberle, Andreas, Garscha, Ulrike, Werz, Oliver, Schuster, Daniela
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528062/
https://ncbi.nlm.nih.gov/pubmed/26088337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.05.045
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