Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum

The farnesoid X receptor (FXR) belonging to the metabolic subfamily of nuclear receptors is a ligand-induced transcriptional activator. Its central function is the physiological maintenance of bile acid homeostasis including the regulation of glucose and lipid metabolism. Accessible structural infor...

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Détails bibliographiques
Auteurs principaux: Grienke, Ulrike, Mihály-Bison, Judit, Schuster, Daniela, Afonyushkin, Taras, Binder, Markus, Guan, Shu-hong, Cheng, Chun-ru, Wolber, Gerhard, Stuppner, Hermann, Guo, De-an, Bochkov, Valery N., Rollinger, Judith M.
Format: Artigo
Langue:Inglês
Publié: Elsevier Science 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254236/
https://ncbi.nlm.nih.gov/pubmed/22014750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.09.039
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