Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation

The farnesoid X receptor (FXR) is involved in glucose and lipid metabolism regulation, which makes it an attractive target for the metabolic syndrome, dyslipidemia, atherosclerosis, and type 2 diabetes. In order to find novel FXR agonists, a structure-based pharmacophore model collection was develop...

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Detalhes bibliográficos
Main Authors: Schuster, Daniela, Markt, Patrick, Grienke, Ulrike, Mihaly-Bison, Judit, Binder, Markus, Noha, Stefan M., Rollinger, Judith M., Stuppner, Hermann, Bochkov, Valery N., Wolber, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254253/
https://ncbi.nlm.nih.gov/pubmed/22018919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.09.056
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