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Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase

Orotidine 5′-monophosphate decarboxylase (ODCase) catalyzes the decarboxylation of orotidine 5′-monophosphate to uridine 5′-monophosphate during pyrimidine nucleotide biosynthesis. This enzyme is one of the most proficient known, exhibiting a rate enhancement of over 17 orders of magnitude over the...

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Библиографические подробности
Главные авторы: Yuan, Ji, Cardenas, Ana Maria, Gilbert, Hiram F, Palzkill, Timothy
Формат: Artigo
Язык:Inglês
Опубликовано: Wiley Subscription Services, Inc., A Wiley Company 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267953/
https://ncbi.nlm.nih.gov/pubmed/21898650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.728
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