Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the para-hydroxyl orientation

In this study, we analyzed the structure activity relationship properties of the small molecule Jak2 inhibitor G6. We synthesized a set of derivatives containing the native para-hydroxyl structure or an alternative meta-hydroxyl structure and examined their Jak2 inhibitory properties. We found that...

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Hlavní autoři: Baskin, Rebekah, Gali, Meghanath, Park, Sung O., Zhao, Zhizhuang Joe, Keserű, György M., Bisht, Kirpal S., Sayeski, Peter P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267892/
https://ncbi.nlm.nih.gov/pubmed/22227213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.12.042
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