A46, a Benzothiophene Derived Compound, Suppresses Jak2-Mediated Pathologic Cell Growth

Hyperkinetic Jak2 tyrosine kinase signaling has been implicated in several hematological disorders including the myeloproliferative neoplasms (MPNs). Effective Jak2 inhibitors can thus have significant therapeutic potential. Here, using structure based virtual screening, we identified a benzothiophe...

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Autors principals: Majumder, Anurima, Magis, Andrew T., Park, Sung O., Figueroa, Nicholas C., Baskin, Rebekah, Kirabo, Annet, Allan, Robert W., Zhao, Zhizhuang Joe, Bisht, Kirpal S., Keserű, György M., Sayeski, Peter P.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237899/
https://ncbi.nlm.nih.gov/pubmed/22019628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2011.10.003
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