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The Stilbenoid Tyrosine Kinase Inhibitor, G6, Suppresses Jak2-V617F-mediated Human Pathological Cell Growth in Vitro and in Vivo

Using structure-based virtual screening, we previously identified a novel stilbenoid inhibitor of Jak2 tyrosine kinase named G6. Here, we hypothesized that G6 suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo. We found that G6 inhibited proliferation of the Jak2-V617...

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Main Authors: Kirabo, Annet, Embury, Jennifer, Kiss, Róbert, Polgár, Tímea, Gali, Meghanath, Majumder, Anurima, Bisht, Kirpal S., Cogle, Christopher R., Keserű, György M., Sayeski, Peter P.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039371/
https://ncbi.nlm.nih.gov/pubmed/21127060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200774
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