Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts

The Hypoxia-inducible transcription Factor (HIF) represents an important adaptive mechanism under hypoxia, whereas sustained activation may also have deleterious effects. HIF activity is determined by the oxygen regulated α-subunits HIF-1α or HIF-2α. Both are regulated by oxygen dependent degradatio...

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Bibliografiska uppgifter
Huvudupphovsmän: Schietke, Ruth E., Hackenbeck, Thomas, Tran, Maxine, Günther, Regina, Klanke, Bernd, Warnecke, Christina L., Knaup, Karl X., Shukla, Deepa, Rosenberger, Christian, Koesters, Robert, Bachmann, Sebastian, Betz, Peter, Schley, Gunnar, Schödel, Johannes, Willam, Carsten, Winkler, Thomas, Amann, Kerstin, Eckardt, Kai-Uwe, Maxwell, Patrick, Wiesener, Michael S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267769/
https://ncbi.nlm.nih.gov/pubmed/22299048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031034
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