Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts

The Hypoxia-inducible transcription Factor (HIF) represents an important adaptive mechanism under hypoxia, whereas sustained activation may also have deleterious effects. HIF activity is determined by the oxygen regulated α-subunits HIF-1α or HIF-2α. Both are regulated by oxygen dependent degradatio...

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Autores principales: Schietke, Ruth E., Hackenbeck, Thomas, Tran, Maxine, Günther, Regina, Klanke, Bernd, Warnecke, Christina L., Knaup, Karl X., Shukla, Deepa, Rosenberger, Christian, Koesters, Robert, Bachmann, Sebastian, Betz, Peter, Schley, Gunnar, Schödel, Johannes, Willam, Carsten, Winkler, Thomas, Amann, Kerstin, Eckardt, Kai-Uwe, Maxwell, Patrick, Wiesener, Michael S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267769/
https://ncbi.nlm.nih.gov/pubmed/22299048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031034
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