The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia: INSIGHTS INTO CELLULAR TRANSFORMATION PROCESSES MEDIATED BY HIF-1

Hypoxia has been shown to promote tumor metastasis and lead to therapy resistance. Recent work has demonstrated that hypoxia represses E-cadherin expression, a hallmark of epithelial to mesenchymal transition, which is believed to amplify tumor aggressiveness. The molecular mechanism of E-cadherin r...

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Detalhes bibliográficos
Main Authors: Schietke, Ruth, Warnecke, Christina, Wacker, Ingrid, Schödel, Johannes, Mole, David R., Campean, Valentina, Amann, Kerstin, Goppelt-Struebe, Margarete, Behrens, Jürgen, Eckardt, Kai-Uwe, Wiesener, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825461/
https://ncbi.nlm.nih.gov/pubmed/20026874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042424
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