Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX

[Image: see text] Two series of novel LOXL2 enzyme inhibitors are described: benzylamines substituted with electron withdrawing groups at the para-position and 2-substituted pyridine-4-ylmethanamines. The most potent compound, (2-chloropyridin-4-yl)methanamine 20 (hLOXL2 IC(50) = 126 nM), was shown...

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Publicat a:ACS Med Chem Lett
Autors principals: Hutchinson, John H., Rowbottom, Martin W., Lonergan, David, Darlington, Janice, Prodanovich, Pat, King, Christopher D., Evans, Jilly F., Bain, Gretchen
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2017
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392766/
https://ncbi.nlm.nih.gov/pubmed/28435530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00014
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