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PKCθ Synergizes with TLR-Dependent TRAF6 Signaling Pathway to Upregulate MUC5AC Mucin via CARMA1

CARD-containing MAGUK protein 1 (CARMA1) plays a crucial role in regulating adaptive immune responses upon T-cell receptor (TCR) activation in T cells. Its role in regulating host mucosal innate immune response such as upregulation of mucin remains unknown. Here we show that CARMA1 acts as a key sig...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jono, Hirofumi, Lim, Jae Hyang, Xu, Haidong, Li, Jian-Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267763/
https://ncbi.nlm.nih.gov/pubmed/22303480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031049
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