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Ionic Residues of Human Serum Transferrin Affect Binding to the Transferrin Receptor and Iron Release

Efficient delivery of iron is critically dependent on the binding of diferric human serum transferrin (hTF) to its specific receptor (TFR) on the surface of actively dividing cells. Internalization of the complex into an endosome precedes iron removal. The return of hTF to the blood to continue the...

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Main Authors: Steere, Ashley N., Miller, Brendan F., Roberts, Samantha E., Byrne, Shaina L., Chasteen, N. Dennis, Smith, Valerie C., MacGillivray, Ross T.A., Mason, Anne B.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267578/
https://ncbi.nlm.nih.gov/pubmed/22191507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201661g
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