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Structure-based mutagenesis reveals critical residues in the transferrin receptor participating in the mechanism of pH-induced iron release from human serum transferrin

The recent crystal structure of two monoferric human serum transferrin (Fe(N)hTF) molecules bound to the soluble portion of the homodimeric transferrin receptor (sTFR) has provided new details of this binding interaction which dictates iron delivery to cells. Specifically, substantial rearrangements...

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Bibliografiske detaljer
Main Authors: Steere, Ashley N., Chasteen, N. Dennis, Miller, Brendan F., Smith, Valerie C., MacGillivray, Ross T.A., Mason, Anne B.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302921/
https://ncbi.nlm.nih.gov/pubmed/22356162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3001038
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