Evidence that His349 acts as a pH-inducible switch to accelerate receptor-mediated iron release from the C-lobe of human transferrin

His349 in human transferrin (hTF) is a residue critical to transferrin receptor (TFR)-stimulated iron release from the C-lobe. To evaluate the importance of His349 on the TFR interaction, it was replaced by alanine, aspartate, lysine, leucine, tryptophan, and tyrosine in a monoferric C-lobe hTF cons...

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Publicado en:J Biol Inorg Chem
Main Authors: Steere, Ashley N., Byrne, Shaina L., Chasteen, N. Dennis, Smith, Valerie C., MacGillivray, Ross T. A., Mason, Anne B.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505821/
https://ncbi.nlm.nih.gov/pubmed/20711621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-010-0694-2
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