Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The mechanistic basis of bilirubin excretion and hyperbilirubinemia syndromes is largely u...

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Main Authors: van de Steeg, Evita, Stránecký, Viktor, Hartmannová, Hana, Nosková, Lenka, Hřebíček, Martin, Wagenaar, Els, van Esch, Anita, de Waart, Dirk R., Oude Elferink, Ronald P.J., Kenworthy, Kathryn E., Sticová, Eva, al-Edreesi, Mohammad, Knisely, A.S., Kmoch, Stanislav, Jirsa, Milan, Schinkel, Alfred H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266790/
https://ncbi.nlm.nih.gov/pubmed/22232210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59526
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