Identification of the Mhc Region as an Asthma Susceptibility Locus in Recombinant Congenic Mice

Mouse models of allergic asthma are characterized by airway hyperreactivity (AHR), Th2-driven eosinophilic airway inflammation, high allergen-specific IgE (anti-OVA IgE) levels in serum, and airway remodeling. Because asthma susceptibility has a strong genetic component, we aimed to identify new ast...

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Main Authors: Nawijn, Martijn C., Piavaux, Benoit J. A., Jeurink, Prescilla V., Gras, Renée, Reinders, Marjan A., Stearns, Timothy, Foote, Simon, Hylkema, Machteld N., Groot, Peter C., Korstanje, Ron, Oosterhout, Antoon J. M. Van
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266060/
https://ncbi.nlm.nih.gov/pubmed/20971879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2009-0369OC
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