GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma

BACKGROUND: Allergic asthma is characterized by airway hyperresponsiveness (AHR) and allergic inflammation of the airways, driven by allergen-specific Th2 cells. The asthma phenotypes and especially AHR are sensitive to the presence and activity of regulatory T (Treg) cells in the lung. Glucocortico...

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Detalhes bibliográficos
Main Authors: Motta, Alexandre C, Vissers, Joost LM, Gras, Renée, Van Esch, Betty CAM, Van Oosterhout, Antoon JM, Nawijn, Martijn C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767348/
https://ncbi.nlm.nih.gov/pubmed/19811658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-10-93
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