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Rapid synthesis of long-chain deoxyribooligonucleotides by the N-methylimidazolide phosphotriester method.

A modified phosphotriester method has been employed for the efficient chemical synthesis of long-chain deoxyribooligonucleotides. During the course of this work, a general and rapid procedure was developed for the preparation of 24-62-mers in solution. Preparative reversed phase column chromatograph...

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Detalhes bibliográficos
Main Authors: Efimov, V A, Buryakova, A A, Reverdatto, S V, Chakhmakhcheva, O G, Ovchinnikov YuA
Formato: Artigo
Idioma:Inglês
Publicado em: 1983
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC326588/
https://ncbi.nlm.nih.gov/pubmed/6324083
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