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Application of new catalytic phosphate protecting groups for the highly efficient phosphotriester oligonucleotide synthesis.

An effective procedure for the synthesis of oligonucleotides by the phosphotriester method has been developed. The procedure is based on the use of phosphate protecting groups enabling O-nucleophilic intramolecular catalysis in the reaction of internucleotide bond formation under the action of aryls...

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Autori principali: Efimov, V A, Buryakova, A A, Dubey, I Y, Polushin, N N, Chakhmakhcheva, O G, Ovchinnikov YuA
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1986
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC311661/
https://ncbi.nlm.nih.gov/pubmed/3748819
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