Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.

A phosphotriester solid phase method on a polyamide support has been used to prepare oligodeoxyribonucleotides up to 12 units long. Compared to solid phase phosphodiester synthesis the new methodology is quicker, more flexible and gives 10-60-fold better overall yields.

Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Gait, M J, Singh, M, Sheppard, R C, Edge, M D, Greene, A R, Heathcliffe, G R, Atkinson, T C, Newton, C R, Markham, A F
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 1980
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323974/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7443540/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/8.5.1081
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