Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.

A phosphotriester solid phase method on a polyamide support has been used to prepare oligodeoxyribonucleotides up to 12 units long. Compared to solid phase phosphodiester synthesis the new methodology is quicker, more flexible and gives 10-60-fold better overall yields.

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Detalhes bibliográficos
Main Authors: Gait, M J, Singh, M, Sheppard, R C, Edge, M D, Greene, A R, Heathcliffe, G R, Atkinson, T C, Newton, C R, Markham, A F
Formato: Artigo
Idioma:Inglês
Publicado em: 1980
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC323974/
https://ncbi.nlm.nih.gov/pubmed/7443540
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