Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein

The identification of HIV-1 envelope glycoprotein (Env) structures that can generate broadly neutralizing antibodies (BNAbs) is pivotal to the development of a successful vaccine against HIV-1 aimed at eliciting effective humoral immune responses. To that end, the production of novel Env structure(s...

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Hauptverfasser: Dey, Antu K., Burke, Brian, Sun, Yide, Sirokman, Klara, Nandi, Avishek, Hartog, Karin, Lian, Ying, Geonnotti, Anthony R., Montefiori, David, Franti, Michael, Martin, Grégoire, Carfi, Andrea, Kessler, Pascal, Martin, Loïc, Srivastava, Indresh K., Barnett, Susan W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265465/
https://ncbi.nlm.nih.gov/pubmed/22291921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030233
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