Stabilizing Exposure of Conserved Epitopes by Structure Guided Insertion of Disulfide Bond in HIV-1 Envelope Glycoprotein

Entry of HIV-1 into target cells requires binding of the viral envelope glycoprotein (Env) to cellular receptors and subsequent conformational changes that culminates in fusion of viral and target cell membranes. Recent structural information has revealed that these conformational transitions are re...

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Autors principals: Kassa, Aemro, Dey, Antu K., Sarkar, Pampi, Labranche, Celia, Go, Eden P., Clark, Daniel F., Sun, Yide, Nandi, Avishek, Hartog, Karin, Desaire, Heather, Montefiori, David, Carfi, Andrea, Srivastava, Indresh K., Barnett, Susan W.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797752/
https://ncbi.nlm.nih.gov/pubmed/24146829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076139
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