Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein

The identification of HIV-1 envelope glycoprotein (Env) structures that can generate broadly neutralizing antibodies (BNAbs) is pivotal to the development of a successful vaccine against HIV-1 aimed at eliciting effective humoral immune responses. To that end, the production of novel Env structure(s...

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Main Authors: Dey, Antu K., Burke, Brian, Sun, Yide, Sirokman, Klara, Nandi, Avishek, Hartog, Karin, Lian, Ying, Geonnotti, Anthony R., Montefiori, David, Franti, Michael, Martin, Grégoire, Carfi, Andrea, Kessler, Pascal, Martin, Loïc, Srivastava, Indresh K., Barnett, Susan W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265465/
https://ncbi.nlm.nih.gov/pubmed/22291921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030233
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