Stabilization of HIV-1 Envelope in the CD4-bound Conformation through Specific Cross-linking of a CD4 Mimetic

CD4 binding on gp120 leads to the exposure of highly conserved regions recognized by the HIV co-receptor CCR5 and by CD4-induced (CD4i) antibodies. A covalent gp120-CD4 complex was shown to elicit CD4i antibody responses in monkeys, which was correlated with control of the HIV virus infection (DeVic...

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Main Authors: Martin, Grégoire, Burke, Brian, Thaï, Robert, Dey, Antu K., Combes, Olivier, Heyd, Bernadette, Geonnotti, Anthony R., Montefiori, David C., Kan, Elaine, Lian, Ying, Sun, Yide, Abache, Toufik, Ulmer, Jeffrey B., Madaoui, Hocine, Guérois, Raphaël, Barnett, Susan W., Srivastava, Indresh K., Kessler, Pascal, Martin, Loïc
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122227/
https://ncbi.nlm.nih.gov/pubmed/21487012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.232272
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