Enhanced Bacteremia in Human Factor H Transgenic Rats Infected by Neisseria meningitidis

Neisseria meningitidis binds the complement downregulating protein, factor H (fH), which enables the organism to evade host defenses. Two fH ligands, fHbp and NspA, are known to bind specifically to human fH. We developed a human fH transgenic infant rat model to investigate the effect of human fH o...

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Bibliographische Detailangaben
Hauptverfasser: Vu, David M., Shaughnessy, Jutamas, Lewis, Lisa A., Ram, Sanjay, Rice, Peter A., Granoff, Dan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264313/
https://ncbi.nlm.nih.gov/pubmed/22104107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05604-11
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