PmrB Mutations Promote Polymyxin Resistance of Pseudomonas aeruginosa Isolated from Colistin-Treated Cystic Fibrosis Patients

Pseudomonas aeruginosa can develop resistance to polymyxin and other cationic antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ regulatory systems can confer low to moderate levels of colistin (polymyxin E) resistance in laboratory strains and clinical isolates of...

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Main Authors: Moskowitz, Samuel M., Brannon, Mark K., Dasgupta, Nandini, Pier, Miyuki, Sgambati, Nicole, Miller, Amanda K., Selgrade, Sara E., Miller, Samuel I., Denton, Miles, Conway, Steven P., Johansen, Helle K., Høiby, Niels
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264203/
https://ncbi.nlm.nih.gov/pubmed/22106224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05829-11
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