A PmrB-Regulated Deacetylase Required for Lipid A Modification and Polymyxin Resistance in Acinetobacter baumannii

Emerging resistance to “last-resort” polymyxin antibiotics in Gram-negative bacteria is a significant threat to public health. We identified the Acinetobacter baumannii NaxD deacetylase as a critical mediator of lipid A modification resulting in polymyxin resistance and demonstrated that naxD is reg...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Chin, Chui-Yoke, Gregg, Kelsey A., Napier, Brooke A., Ernst, Robert K., Weiss, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649237/
https://ncbi.nlm.nih.gov/pubmed/26459891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00515-15
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