The pmrCAB Operon Mediates Polymyxin Resistance in Acinetobacter baumannii ATCC 17978 and Clinical Isolates through Phosphoethanolamine Modification of Lipid A

The emergence of multidrug resistance among Acinetobacter baumannii is leading to an increasing dependence on the use of polymyxins as last-hope antibiotics. Here, we utilized genetic and biochemical methods to define the involvement of the pmrCAB operon in polymyxin resistance in this organism. Seq...

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Библиографические подробности
Главные авторы: Arroyo, Luis A., Herrera, Carmen M., Fernandez, Lucia, Hankins, Jessica V., Trent, M. Stephen, Hancock, Robert E. W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2011
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147623/
https://ncbi.nlm.nih.gov/pubmed/21646482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00256-11
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