Polymyxin Resistance of Pseudomonas aeruginosa phoQ Mutants Is Dependent on Additional Two-Component Regulatory Systems

Pseudomonas aeruginosa can develop resistance to polymyxin as a consequence of mutations in the PhoPQ regulatory system, mediated by covalent lipid A modification. Transposon mutagenesis of a polymyxin-resistant phoQ mutant defined 41 novel loci required for resistance, including two regulatory syst...

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Main Authors: Gutu, Alina D., Sgambati, Nicole, Strasbourger, Pnina, Brannon, Mark K., Jacobs, Michael A., Haugen, Eric, Kaul, Rajinder K., Johansen, Helle Krogh, Høiby, Niels, Moskowitz, Samuel M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2013
Ábhair:
Mechanisms of Resistance
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632916/
https://ncbi.nlm.nih.gov/pubmed/23459479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02353-12
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