PhoQ Mutations Promote Lipid A Modification and Polymyxin Resistance of Pseudomonas aeruginosa Found in Colistin-Treated Cystic Fibrosis Patients

Pseudomonas aeruginosa can develop resistance to polymyxin and other cationic antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ regulatory systems can confer low to moderate levels of polymyxin resistance (MICs of 8 to 64 mg/liter) in laboratory and clinical strai...

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Hlavní autoři: Miller, Amanda K., Brannon, Mark K., Stevens, Laurel, Johansen, Helle Krogh, Selgrade, Sara E., Miller, Samuel I., Høiby, Niels, Moskowitz, Samuel M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232818/
https://ncbi.nlm.nih.gov/pubmed/21968359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05391-11
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