PhoQ Mutations Promote Lipid A Modification and Polymyxin Resistance of Pseudomonas aeruginosa Found in Colistin-Treated Cystic Fibrosis Patients

Pseudomonas aeruginosa can develop resistance to polymyxin and other cationic antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ regulatory systems can confer low to moderate levels of polymyxin resistance (MICs of 8 to 64 mg/liter) in laboratory and clinical strai...

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Detalhes bibliográficos
Main Authors: Miller, Amanda K., Brannon, Mark K., Stevens, Laurel, Johansen, Helle Krogh, Selgrade, Sara E., Miller, Samuel I., Høiby, Niels, Moskowitz, Samuel M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232818/
https://ncbi.nlm.nih.gov/pubmed/21968359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05391-11
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