Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols

Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels. Ethanol potentiates glycine activation of the GlyR, and putative binding sites for alcohol are located in the transmembrane (TM) domains between and within subunits. To alter alcohol sensitivity of GlyR, we introduced two mutations...

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Bibliografiska uppgifter
Huvudupphovsmän: Borghese, Cecilia M., Blednov, Yuri A., Quan, Yu, Iyer, Sangeetha V., Xiong, Wei, Mihic, S. John, Zhang, Li, Lovinger, David M., Trudell, James R., Homanics, Gregg E., Harris, R. Adron
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2012
Ämnen:
Neuropharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263968/
https://ncbi.nlm.nih.gov/pubmed/22037201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.185116
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