Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols

Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels. Ethanol potentiates glycine activation of the GlyR, and putative binding sites for alcohol are located in the transmembrane (TM) domains between and within subunits. To alter alcohol sensitivity of GlyR, we introduced two mutations...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Borghese, Cecilia M., Blednov, Yuri A., Quan, Yu, Iyer, Sangeetha V., Xiong, Wei, Mihic, S. John, Zhang, Li, Lovinger, David M., Trudell, James R., Homanics, Gregg E., Harris, R. Adron
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2012
Aiheet:
Neuropharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263968/
https://ncbi.nlm.nih.gov/pubmed/22037201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.185116
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