Mutations M287L and Q266I in the Glycine Receptor α1 Subunit Change Sensitivity to Volatile Anesthetics in Oocytes and Neurons, but Not the Minimal Alveolar Concentration in Knockin Mice

BACKGROUND: Volatile anesthetics (VAs) alter the function of key central nervous system proteins but it is not clear which, if any, of these targets mediates the immobility produced by VAs in the face of noxious stimulation. A leading candidate is the glycine receptor, a ligand-gated ion channel imp...

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Auteurs principaux: Borghese, Cecilia M., Xiong, Wei, Oh, S. Irene, Ho, Angel, Mihic, S. John, Zhang, Li, Lovinger, David M., Homanics, Gregg E., Eger, Edmond I, Harris, R. Adron
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447119/
https://ncbi.nlm.nih.gov/pubmed/22885675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e31826a0d93
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