Synthesis of Biphenyl Proteomimetics as Estrogen Receptor-alpha Coactivator Binding Inhibitors

[Image: see text] A novel series of biphenyl proteomimetic compounds were designed as estrogen receptor-alpha (ERα) coactivator binding inhibitors. Synthesis was accomplished through a convergent approach, employing Suzuki coupling chemistry to ligate the individual modular units. Initial biological...

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Main Authors: Williams, Anna B., Weiser, Patrick T., Hanson, Robert N., Gunther, Jillian R., Katzenellenbogen, John A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263526/
https://ncbi.nlm.nih.gov/pubmed/19902964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol901999f
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