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Synthesis and Biological Evaluation of Guanylhydrazone Coactivator Binding Inhibitors for the Estrogen Receptor
Most patients with hormone-responsive breast cancer eventually develop resistance to traditional antiestrogens such as tamoxifen, and this has become a major obstacle in their treatment. We prepared and characterized the activity of a series of 16 guanylhydrazone small molecules that are designed to...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613833/ https://ncbi.nlm.nih.gov/pubmed/18976929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.10.007 |
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