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Steroidal Bivalent Ligands for the Estrogen Receptor: Design, Synthesis, Characterization and Binding Affinities

Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ERα dimers as a template. The syntheses of several 17α-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent liga...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: LaFrate, Andrew L., Carlson, Kathryn E., Katzenellenbogen, John A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2009
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178464/
https://ncbi.nlm.nih.gov/pubmed/19394231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.04.016
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