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Steroidal Bivalent Ligands for the Estrogen Receptor: Design, Synthesis, Characterization and Binding Affinities
Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ERα dimers as a template. The syntheses of several 17α-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent liga...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3178464/ https://ncbi.nlm.nih.gov/pubmed/19394231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.04.016 |
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