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Amphipathic Benzenes Are Designed Inhibitors of the Estrogen Receptor α/Steroid Receptor Coactivator Interaction

We report here on the design, synthesis and evaluation of small molecule inhibitors of the interaction between a steroid receptor coactivator and estrogen receptor α. These inhibitors are based upon an amphipathic benzene scaffold whose hydrophobic face mimics the leucine-rich α-helical consensus se...

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Hlavní autoři: Gunther, Jillian R., Moore, Terry W., Collins, Margaret L., Katzenellenbogen, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427189/
https://ncbi.nlm.nih.gov/pubmed/18484708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb800056r
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