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Discovering Small Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency
Small molecules, namely, coactivator binding inhibitors (CBIs), that block estrogen signaling by directly inhibiting the interaction of the estrogen receptor (ER) with coactivator proteins act in a fundamentally different way than traditional antagonists, which displace the endogenous ligand estradi...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177402/ https://ncbi.nlm.nih.gov/pubmed/21365764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000507 |
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