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Discovering Small Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency

Small molecules, namely, coactivator binding inhibitors (CBIs), that block estrogen signaling by directly inhibiting the interaction of the estrogen receptor (ER) with coactivator proteins act in a fundamentally different way than traditional antagonists, which displace the endogenous ligand estradi...

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Dettagli Bibliografici
Autori principali: Sun, Aiming, Moore, Terry W., Gunther, Jillian R., Kim, Mi-Sun, Rhoden, Eric, Du, Yuhong, Fu, Haian, Snyder, James P., Katzenellenbogen, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177402/
https://ncbi.nlm.nih.gov/pubmed/21365764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000507
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