STRUCTURAL BASIS OF Bcl-x(L) RECOGNITION BY A BH3-MIMETIC α/β-PEPTIDE GENERATED VIA SEQUENCE-BASED DESIGN

The crystal structure of a complex between the pro-survival protein Bcl-x(L) and an α/β-peptide 21-mer is described. The α/β-peptide contains six β-amino acid residues distributed periodically throughout the sequence and adopts an α-helix-like conformation that mimics the bioactive shape of the Puma...

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Autori principali: Lee, Erinna F., Smith, Brian J., Horne, W. Seth, Mayer, Kelsey N., Evangelista, Marco, Colman, Peter M., Gellman, Samuel H., Fairlie, W. Douglas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263372/
https://ncbi.nlm.nih.gov/pubmed/21744457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100314
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