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STRUCTURAL BASIS OF Bcl-x(L) RECOGNITION BY A BH3-MIMETIC α/β-PEPTIDE GENERATED VIA SEQUENCE-BASED DESIGN
The crystal structure of a complex between the pro-survival protein Bcl-x(L) and an α/β-peptide 21-mer is described. The α/β-peptide contains six β-amino acid residues distributed periodically throughout the sequence and adopts an α-helix-like conformation that mimics the bioactive shape of the Puma...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263372/ https://ncbi.nlm.nih.gov/pubmed/21744457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100314 |
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