Genomic and phenotypic analysis of BRCA2 mutated breast cancers reveals co-occurring changes linked to progression

BACKGROUND: Inherited mutations in the BRCA2 gene greatly increase the risk of developing breast cancer. Consistent with an important role for BRCA2 in error-free DNA repair, complex genomic changes are frequently observed in tumors derived from BRCA2 mutation carriers. Here, we explore the impact o...

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Bibliographic Details
Main Authors: Stefansson, Olafur A, Jonasson, Jon G, Olafsdottir, Kristrun, Bjarnason, Hordur, Th Johannsson, Oskar, Bodvarsdottir, Sigridur K, Valgeirsdottir, Sigridur, Eyfjord, Jorunn E
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262207/
https://ncbi.nlm.nih.gov/pubmed/21958427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3020
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